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Lima, Naiana G.P.B.; De Sousa, Damião P.; Pimenta, Flávia Cristina F.; Alves, Mateus F.; De Souza, Fábio S.; Macedo, Rui O.; Cardoso, Ricardo B.; de Morais, Liana Clébia S.L.; Melo Diniz, Margareth de Fátima F.; de Almeida, Reinaldo Nóbrega
Pharmacology, biochemistry and behavior, January 2013, 2013-Jan, 2013-01-00, 20130101, Letnik: 103, Številka: 3Journal Article
The traditional use of essential oils in aromatherapy has offered numerous health benefits. However, few scientific studies have been conducted with these oils to confirm their therapeutic efficacy. (+)-Limonene is a chemical constituent of various bioactive essential oils. The present study reports on the anxiolytic-like effects of (+)-limonene in an elevated maze model of anxiety in mice. At concentrations of 0.5% and 1.0%, (+)-limonene, administered to mice by inhalation, significantly modified all the parameters evaluated in the elevated plus maze test. The pharmacological effect of inhaled (+)-limonene (1%) was not blocked by flumazenil. Analysis of (+)-limonene using gas chromatography–mass spectrometry (GC–MS) showed its volatility to be high. These data suggest possible connections between the volatility of (+)-limonene and its anxiolytic-like effect on the parameters evaluated in the elevated plus maze test. The data indicate that (+)-limonene could be used in aromatherapy as an antianxiety agent. Display omitted ► Inhaled limonene ► Increases open entries and open duration in elevated plus-maze. ► Anxiolytic properties in mice
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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