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Guerra, Joyce Ferreira da Costa; Maciel, Poliane Silva; de Abreu, Isabel Cristina Mallosto Emerich; Pereira, Renata Rebeca; Silva, Maisa; Cardoso, Leandro de Morais; Pinheiro-Sant'Ana, Helena Maria; Lima, Wanderson Geraldo de; Silva, Marcelo Estáquio; Pedrosa, Maria Lúcia
Journal of functional foods, April 2015, 2015-04-00, 2015-04-01, Letnik: 14Journal Article
•Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease.•Açai (Euterpe oleracea) fruit contains high levels of polyphenols, e.g. anthocyanins.•Mice with high-fat diet-induced NAFLD received oral aqueous açai extract (AAE).•AAE increased adiponectin levels, insulin sensitivity and PPAR-α-mediated fatty acid oxidation, decreasing liver lipids. Polyphenols, especially anthocyanins, have been considered promising for the prevention of nonalcoholic fatty liver disease (NAFLD). This study investigated whether açai (Euterpe oleracea Mart.), a source of anthocyanins and recognized as one of the new “superfruits”, could alleviate high-fat diet (HFD)-induced NAFLD in mice. In HFD mice, aqueous açai extract (AAE) administration (3 g/kg) for six weeks improved insulin resistance index and increased adiponectin mRNA expression in adipose tissue and serum levels. Furthermore, AAE decreased the total liver triacylglycerol content and attenuated HFD-induced hepatic steatosis. This reduced hepatic lipid content was associated with AAE-mediated up-regulation of genes involved in adiponectin signaling, including adiponectin receptor 2, PPAR-α, and its target gene, carnitine palmitoyltransferase. Thus, dietary açai can protect liver from steatosis through its enhancement of adiponectin levels, improvement of insulin sensitivity, and increase in PPAR-α-mediated fatty acid oxidation.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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