The goal of this investigation is to test the barium boro-silicate glass-ceramics with different additives against gamma radiation using the FLUKA Monte Carlo code. On four different glass-ceramics samples, the effect of an equal quantity of Al2O3, La2O3, Gd2O3, and Dy2O3 with barium borosilicate glass-ceramics on the radiation shielding capabilities of the glass-ceramics was investigated. In the examined glass ceramics, densities were obtained to investigate glass samples. The densities obtained were 3.92, 4.432, 4.52, and 4.88 g/cm3, respectively. BBSDy sample has the highest density which indicates that it is more effective for radiation shielding. The shielding parameters have been calculated at 0.356, 0.662, 1.173, and 1.333 MeV. The obtained results have been compared with the NistXCOM web page and Phy-X/PSD platform. The results showed a good agreement between FLUKA code, NistXCOM, and Phy-X/PSD. The calculated shielding parameters increase with additive (Al2O3, La2O3, Gd2O3, and Dy2O3). Moreover, the 50BaO–15SiO2–30B2O3–5Al2O3-5Dy2O3 specimen has the best radiation shielding features among the other glass-ceramics. In conclusion, the BBSDY sample containing 5 mol per cent 5 mol% Dy–III–Oxide would be the most effective in terms of radiation shielding, based on the results obtained in this study. When Dy-III Oxide concentrations were increased, linear and mass attenuation coefficient values were significantly increased, which contributed directly to the development of radiation shielding characteristics in the glass-ceramic.