The paper demonstrates improved structural low-frequency vibroacoustic performance of cross-laminated timber (CLT) floor panels by informed selection of the wood material. The use of wood species and strength classes that are not traditionally assigned to CLT panels was investigated in order to study their influence on dynamic characteristics and vibroacoustic response metrics. The potential of each of the orthotropic material properties to alternate the vibration response was examined to determine the governing parameters of the low-frequency vibroacoustic performance. The effects on transfer mobility response functions, and eigenfrequencies and mode shapes were used for a rigorous performance study of the panels. It was found that using laminations with stiffness properties typical for hardwoods ash, beech, and birch can significantly improve the performance of a CLT floor panel, and they outperform laminations of typical softwood strength classes.