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Rocha-Santos, Gerlan; Cuba, Gabriel T.; Cayô, Rodrigo; Streling, Ana Paula; Nodari, Carolina S.; Gales, Ana C.; Pignatari, Antonio C.C.; Nicolau, David P.; Kiffer, Carlos R.V.
Diagnostic microbiology and infectious disease, June 2021, 2021-Jun, 2021-06-00, 20210601, Letnik: 100, Številka: 2Journal Article
•Combined therapies have been evaluated against MβL-producing P. aeruginosa isolates.•TLc + AT combination presented synergistic effect against SPM-1-producing strains.•TLc+ C/T combination presented antagonistic effect against SPM-1-producing strains. Minimal inhibitory concentrations (MICs) of ticarcillin/clavulanic acid (TLc), ceftolozane/tazobactam (C/T), and aztreonam (AT) were determined for 6 SPM-1-producing Pseudomonas aeruginosa (PSA) using Etest® strips and the synergistic effect of such antimicrobials against was evaluated by gradient diffusion strip crossing (GDSC) test. The fraction inhibitory concentration indexes (FICI) were calculated and showed a synergistic (n = 3) and additive (n = 2) effects of TLc + AT against SPM-1 producers, while TLc + C/T combination caused no effect. Average MIC reduction of TLc and AT by GDSC was 3-fold and 2-fold dilutions, respectively. Thus, TLc + AT might be a candidate as a combination therapy to treat SPM-1-producing PSA infections.
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Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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