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Zhong, Franklin L.; Batista, Luis F.Z.; Freund, Adam; Pech, Matthew F.; Venteicher, Andrew S.; Artandi, Steven E.
Cell, 08/2012, Letnik: 150, Številka: 3Journal Article
Telomere synthesis in cancer cells and stem cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited to telomeres through interactions with telomere-binding proteins. Here, we show that the OB-fold domain of the telomere-binding protein TPP1 recruits telomerase to telomeres through an association with the telomerase reverse transcriptase TERT. When tethered away from telomeres and other telomere-binding proteins, the TPP1 OB-fold domain is sufficient to recruit telomerase to a heterologous chromatin locus. Expression of a minimal TPP1 OB-fold inhibits telomere maintenance by blocking access of telomerase to its cognate binding site at telomeres. We identify amino acids required for the TPP1-telomerase interaction, including specific loop residues within the TPP1 OB-fold domain and individual residues within TERT, some of which are mutated in a subset of pulmonary fibrosis patients. These data define a potential interface for telomerase-TPP1 interaction required for telomere maintenance and implicate defective telomerase recruitment in telomerase-related disease. Display omitted ► Enforced expression of telomerase forms neo-Cajal bodies at telomeres ► TPP1 OB-fold domain recruits telomerase to a heterologous chromatin locus ► TPP1-OB alone sequesters telomerase within Cajal bodies and causes telomere shortening ► OB-fold mutations and some disease mutations in TERT block telomerase recruitment The shelterin component TPP1 recruits telomerase from storage in Cajal bodies via a direct interaction with the enzyme’s catalytic subunit TERT. Mutations in TERT found associated with an idiopathic lung disease disrupt the interaction and impair telomerase mobilization.
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