•Optimum inclination for maximum heat flux changes with latitude of location.•Optimum inclination for maximum heat flux also changes local solar time.•Maximum flow rate increases with increasing of riser tube size.•Maximum mass flow rate is obtained at different inclinations for different risers.•Length of two-phase region depends on inclination angles but not riser tube size. In this work, the effect of riser diameter and its inclination angle on system parameters in a two-phase closed loop thermosyphon solar water heater has been numerically investigated. Here, receivable heat flux by the collector, circulating mass flow rate, driving pressure, total pressure drop, heat transfer coefficient in risers and collector efficiency are defined as system parameters. For this aim, a model of two-phase thermosyphon solar water heater that is acceptable for various inclinations is presented and variations of riser diameter and inclination are considered. The riser tube size is varied from 1.25cm to 2.5cm with inclination range 2–75°. The system absolute pressure is set as 3567Pa and water is chosen as working fluid. The results show that higher inclination angle is required for higher latitude location to obtain maximum solar heat flux. At local solar noon of 21.996 north latitude, the optimum inclination angle increases in the range of 24–44° with increasing of riser diameter giving maximum circulating mass flow rate from 0.02288kg/s to 0.03876kg/s. The longer two-phase heat transfer characteristics can be obtained at smaller inclination angles and mass flow rate for all riser tube sizes. Therefore, it is observed that the optimum inclination angles and diameters for solar heat flux, circulating mass flow rate and heat transfer coefficient in two-phase thermosyphon systemdo not coincide. From this work, better understanding and useful information are provided for constructing two-phase thermosyphon solar heaters.