E-viri
Recenzirano
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He, Wen-Zhen; Yang, Mi; Jiang, Yangzi; He, Chen; Sun, Yu-Chen; Liu, Ling; Huang, Mei; Jiao, Yu-Rui; Chen, Kai-Xuan; Hou, Jing; Huang, Min; Xu, Yi-Li; Feng, Xu; Liu, Ya; Guo, Qi; Peng, Hui; Huang, Yan; Su, Tian; Xiao, Ye; Li, Yusheng; Zeng, Chao; Lei, Guanghua; Luo, Xiang-Hang; Li, Chang-Jun
Cell death & disease, 05/2022, Letnik: 13, Številka: 5Journal Article
A specific bone capillary subtype, namely type H vessels, with high expression of CD31 and endomucin, was shown to couple angiogenesis and osteogenesis recently. The number of type H vessels in bone tissue declines with age, and the underlying mechanism for this reduction is unclear. Here, we report that microRNA-188-3p (miR-188-3p) involves this process. miRNA-188-3p expression is upregulated in skeletal endothelium and negatively regulates the formation of type H vessels during ageing. Mice with depletion of miR-188 showed an alleviated age-related decline in type H vessels. In contrast, endothelial-specific overexpression of miR-188-3p reduced the number of type H vessels, leading to decreased bone mass and delayed bone regeneration. Mechanistically, we found that miR-188 inhibits type H vessel formation by directly targeting integrin β3 in endothelial cells. Our findings indicate that miR-188-3p is a key regulator of type H vessel formation and may be a potential therapeutic target for preventing bone loss and accelerating bone regeneration.
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Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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