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Mizrak, Dogukan; Levitin, Hanna Mendes; Delgado, Ana C.; Crotet, Valerie; Yuan, Jinzhou; Chaker, Zayna; Silva-Vargas, Violeta; Sims, Peter A.; Doetsch, Fiona
Cell reports, 01/2019, Letnik: 26, Številka: 2Journal Article
The ventricular-subventricular zone (V-SVZ) harbors adult neural stem cells. V-SVZ neural stem cells exhibit features of astrocytes, have a regional identity, and depending on their location in the lateral or septal wall of the lateral ventricle, generate different types of neuronal and glial progeny. We performed large-scale single-cell RNA sequencing to provide a molecular atlas of cells from the lateral and septal adult V-SVZ of male and female mice. This revealed regional and sex differences among adult V-SVZ cells. We uncovered lineage potency bias at the single-cell level among lateral and septal wall astrocytes toward neurogenesis and oligodendrogenesis, respectively. Finally, we identified transcription factor co-expression modules marking key temporal steps in neurogenic and oligodendrocyte lineage progression. Our data suggest functionally important spatial diversity in neurogenesis and oligodendrogenesis in the adult brain and reveal molecular correlates of adult NSC dormancy and lineage specialization. Display omitted •Single-cell transcriptomics of >41,000 cells from adult V-SVZ neural stem cell niche•Regional and sex differences in lateral and septal adult V-SVZ in males and females•Identify transcription factor co-expression modules and lineage potency markers•Regional biases for neuronal and oligodendrocyte lineages in the adult V-SVZ Mizrak et al. performed large-scale, single-cell RNA sequencing of the adult ventricular-subventricular zone neural stem cell niche. They identify regional differences between the lateral wall and septal wall, as well as sex differences in cell types and signaling pathways.
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