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Jean, Julie; Farrell, David S.; Farrelly, Angela M.; Toomey, Sinead; Barlow, James W.
Heliyon, 09/2018, Letnik: 4, Številka: 9Journal Article
We designed and synthesised a series of novel chalcones, incorporating the heterocyclic framework of 2,2-dimethyl-2,3-dihydro-4(1H)-quinolinone, which was prepared via Sonogashira coupling of a substituted orthoaniline under aqueous conditions using Pd catalysis followed by acid-mediated cyclisation. The compounds were screened against the NCI-N87 and DLD-1 cancer cell lines, with most compounds showing low micromolar cytotoxic activity.
