E-viri
Recenzirano
Odprti dostop
-
Wang, Heming; Lane, Jacqueline M; Jones, Samuel E; Dashti, Hassan S; Ollila, Hanna M; Wood, Andrew R; van Hees, Vincent T; Brumpton, Ben; Winsvold, Bendik S; Kantojärvi, Katri; Palviainen, Teemu; Cade, Brian E; Sofer, Tamar; Song, Yanwei; Patel, Krunal; Anderson, Simon G; Bechtold, David A; Bowden, Jack; Emsley, Richard; Kyle, Simon D; Little, Max A; Loudon, Andrew S; Scheer, Frank A J L; Purcell, Shaun M; Richmond, Rebecca C; Spiegelhalder, Kai; Tyrrell, Jessica; Zhu, Xiaofeng; Hublin, Christer; Kaprio, Jaakko A; Kristiansson, Kati; Sulkava, Sonja; Paunio, Tiina; Hveem, Kristian; Nielsen, Jonas B; Willer, Cristen J; Zwart, John-Anker; Strand, Linn B; Frayling, Timothy M; Ray, David; Lawlor, Deborah A; Rutter, Martin K; Weedon, Michael N; Redline, Susan; Saxena, Richa
Nature communications, 08/2019, Letnik: 10, Številka: 1Journal Article
Excessive daytime sleepiness (EDS) affects 10-20% of the population and is associated with substantial functional deficits. Here, we identify 42 loci for self-reported daytime sleepiness in GWAS of 452,071 individuals from the UK Biobank, with enrichment for genes expressed in brain tissues and in neuronal transmission pathways. We confirm the aggregate effect of a genetic risk score of 42 SNPs on daytime sleepiness in independent Scandinavian cohorts and on other sleep disorders (restless legs syndrome, insomnia) and sleep traits (duration, chronotype, accelerometer-derived sleep efficiency and daytime naps or inactivity). However, individual daytime sleepiness signals vary in their associations with objective short vs long sleep, and with markers of sleep continuity. The 42 sleepiness variants primarily cluster into two predominant composite biological subtypes - sleep propensity and sleep fragmentation. Shared genetic links are also seen with obesity, coronary heart disease, psychiatric diseases, cognitive traits and reproductive ageing.
Avtor
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.