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Thijssen, Victor L. J. L.; Postel, Ruben; Brandwijk, Ricardo J. M. G. E.; Dings, Ruud P. M.; Nesmelova, Irina; Satijn, Sietske; Verhofstad, Nicole; Nakabeppu, Yusaku; Baum, Linda G.; Bakkers, Jeroen; Mayo, Kevin H.; Poirier, Françoise; Griffioen, Arjan W.
Proceedings of the National Academy of Sciences - PNAS, 10/2006, Letnik: 103, Številka: 43Journal Article
We describe that galectin-1 (gal-1) is a receptor for the angiogenesis inhibitor anginex, and that the protein is crucial for tumor angiogenesis. gal-1 is overexpressed in endothelial cells of different human tumors. Expression knockdown in cultured endothelial cells inhibits cell proliferation and migration. The importance of gal-1 in angiogenesis is illustrated in the zebrafish model, where expression knockdown results in impaired vascular guidance and growth of dysfunctional vessels. The role of gal-1 in tumor angiogenesis is demonstrated in gal-1-null mice, in which tumor growth is markedly impaired because of insufficient tumor angiogenesis. Furthermore, tumor growth in gal-I-null mice no longer responds to antiangiogenesis treatment by anginex. Thus, gal-1 regulates tumor angiogenesis and is a target for angiostatic cancer therapy.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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