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Wang, Ling; Zhao, Juan; Nguyen, Lam N T; Adkins, James L; Schank, Madison; Khanal, Sushant; Nguyen, Lam N; Dang, Xindi; Cao, Dechao; Thakuri, Bal Krishna Chand; Lu, Zeyuan; Zhang, Jinyu; Zhang, Yi; Wu, Xiao Y; El Gazzar, Mohamed; Ning, Shunbin; Moorman, Jonathan P; Yao, Zhi Q
Scientific reports, 03/2021, Letnik: 11, Številka: 1Journal Article
The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cell-cell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. Importantly, we find that COVID-19 convalescent plasma with high titers of IgG neutralizing antibodies can block cell-cell fusion and virus entry by interfering with the SARS-CoV-2-S/ACE2 or SARS-CoV-S/ACE2 interactions. These findings suggest that COVID-19 convalescent plasma may not only inhibit SARS-CoV-2-S but also cross-neutralize SARS-CoV-S-mediated membrane fusion and virus entry, supporting its potential as a preventive and/or therapeutic agent against SARS-CoV-2 as well as other SARS-CoV infections.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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