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Rozenberg, Perri; Reichman, Hadar; Zab-Bar, Israel; Itan, Michal; Pasmanik-Chor, Metsada; Bouffi, Carine; Qimron, Udi; Bachelet, Ido; Fulkerson, Patricia C; Rothenberg, Marc E; Munitz, Ariel
Scientific reports, 07/2017, Letnik: 7, Številka: 1Journal Article
Eosinophils and their associated cytokines IL-4 and IL-5 are emerging as central orchestrators of the immune-metabolic axis. Herein, we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpoint that modifies the ability of eosinophils to regulate metabolic outcomes. Generation of Il5 /Cd300f mice revealed marked and distinct increases in eosinophil levels and their production of IL-4 in the white and brown adipose tissues. Consequently, Il5 /Cd300f mice had increased alternatively activated macrophage accumulation in the adipose tissue. Cd300f mice displayed age-related accumulation of eosinophils and macrophages in the adipose tissue and decreased adipose tissue weight, which was associated with decreased diet-induced weight gain and insulin resistance. Notably, Il5 /CD300f were protected from diet-induced weight gain and glucose intolerance. These findings highlight the cross-talk between IL-5 receptor and CD300f as a novel pathway regulating adipose tissue eosinophils and offer new entry points for therapeutic intervention for obesity and its complications.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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