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Reuben, Alexandre; Zhang, Jiexin; Chiou, Shin-Heng; Gittelman, Rachel M; Li, Jun; Lee, Won-Chul; Fujimoto, Junya; Behrens, Carmen; Liu, Xiaoke; Wang, Feng; Quek, Kelly; Wang, Chunlin; Kheradmand, Farrah; Chen, Runzhe; Chow, Chi-Wan; Lin, Heather; Bernatchez, Chantale; Jalali, Ali; Hu, Xin; Wu, Chang-Jiun; Eterovic, Agda Karina; Parra, Edwin Roger; Yusko, Erik; Emerson, Ryan; Benzeno, Sharon; Vignali, Marissa; Wu, Xifeng; Ye, Yuanqing; Little, Latasha D; Gumbs, Curtis; Mao, Xizeng; Song, Xingzhi; Tippen, Samantha; Thornton, Rebecca L; Cascone, Tina; Snyder, Alexandra; Wargo, Jennifer A; Herbst, Roy; Swisher, Stephen; Kadara, Humam; Moran, Cesar; Kalhor, Neda; Zhang, Jianhua; Scheet, Paul; Vaporciyan, Ara A; Sepesi, Boris; Gibbons, Don L; Robins, Harlan; Hwu, Patrick; Heymach, John V; Sharma, Padmanee; Allison, James P; Baladandayuthapani, Veera; Lee, Jack J; Davis, Mark M; Wistuba, Ignacio I; Futreal, P Andrew; Zhang, Jianjun
Nature communications, 01/2020, Letnik: 11, Številka: 1Journal Article
Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the T cells in the lungs of patients with NSCLC. Here, we report T cell repertoire analysis in a cohort of 236 early-stage NSCLC patients. T cell repertoire attributes are associated with clinicopathologic features, mutational and immune landscape. A considerable proportion of the most prevalent T cells in tumors are also prevalent in the uninvolved tumor-adjacent lungs and appear specific to shared background mutations or viral infections. Patients with higher T cell repertoire homology between the tumor and uninvolved tumor-adjacent lung, suggesting a less tumor-focused T cell response, exhibit inferior survival. These findings indicate that a concise understanding of antigens and T cells in NSCLC is needed to improve therapeutic efficacy and reduce toxicity with immunotherapy, particularly adoptive T cell therapy.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Vir: Osebne bibliografije
in: SICRIS
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