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Zhang, Liang; Jiang, Yao; He, Jinhang; Chen, Junyu; Qi, Ruoyao; Yuan, Lunzhi; Shao, Tiange; Zhao, Hui; Chen, Congjie; Chen, Yaode; Wang, Xijing; Lei, Xing; Gao, Qingxiang; Zhuang, Chunlan; Zhou, Ming; Ma, Jian; Liu, Wei; Yang, Man; Fu, Rao; Wu, Yangtao; Chen, Feng; Xiong, Hualong; Nie, Meifeng; Chen, Yiyi; Wu, Kun; Fang, Mujin; Wang, Yingbin; Zheng, Zizheng; Huang, Shoujie; Ge, Shengxiang; Cheng, Shih Chin; Zhu, Huachen; Cheng, Tong; Yuan, Quan; Wu, Ting; Zhang, Jun; Chen, Yixin; Zhang, Tianying; Li, Changgui; Qi, Hai; Guan, Yi; Xia, Ningshao
Nature communications, 07/2023, Letnik: 14, Številka: 1Journal Article
The emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants and "anatomical escape" characteristics threaten the effectiveness of current coronavirus disease 2019 (COVID-19) vaccines. There is an urgent need to understand the immunological mechanism of broad-spectrum respiratory tract protection to guide broader vaccines development. Here we investigate immune responses induced by an NS1-deleted influenza virus vectored intranasal COVID-19 vaccine (dNS1-RBD) which provides broad-spectrum protection against SARS-CoV-2 variants in hamsters. Intranasal delivery of dNS1-RBD induces innate immunity, trained immunity and tissue-resident memory T cells covering the upper and lower respiratory tract. It restrains the inflammatory response by suppressing early phase viral load post SARS-CoV-2 challenge and attenuating pro-inflammatory cytokine (Il6, Il1b, and Ifng) levels, thereby reducing excess immune-induced tissue injury compared with the control group. By inducing local cellular immunity and trained immunity, intranasal delivery of NS1-deleted influenza virus vectored vaccine represents a broad-spectrum COVID-19 vaccine strategy to reduce disease burden.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
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Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
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Vir: Osebne bibliografije
in: SICRIS
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