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Páez-Franco, José C; Torres-Ruiz, Jiram; Sosa-Hernández, Víctor A; Cervantes-Díaz, Rodrigo; Romero-Ramírez, Sandra; Pérez-Fragoso, Alfredo; Meza-Sánchez, David E; Germán-Acacio, Juan Manuel; Maravillas-Montero, José L; Mejía-Domínguez, Nancy R; Ponce-de-León, Alfredo; Ulloa-Aguirre, Alfredo; Gómez-Martín, Diana; Llorente, Luis
Scientific reports, 03/2021, Letnik: 11, Številka: 1Journal Article
We identified the main changes in serum metabolites associated with severe (n = 46) and mild (n = 19) COVID-19 patients by gas chromatography coupled to mass spectrometry. The modified metabolic profiles were associated to an altered amino acid catabolism in hypoxic conditions. Noteworthy, three α-hydroxyl acids of amino acid origin increased with disease severity and correlated with altered oxygen saturation levels and clinical markers of lung damage. We hypothesize that the enzymatic conversion of α-keto-acids to α- hydroxyl-acids helps to maintain NAD recycling in patients with altered oxygen levels, highlighting the potential relevance of amino acid supplementation during SARS-CoV-2 infection.
