Two new series of hybrid quinoline-sulfonamide complexes (M : Zn , Cu , Co and Cd ) derivatives ( ) were designed, synthesized and tested for their antimicrobial activity. The synthesis is straightforward and efficient, involving two steps: acylation of aminoquinoline followed by complexation with metal acetate (Cu , Co and Cd ) or chloride (Zn ). The synthesized compounds were characterized by FTIR and NMR spectroscopy and by X-ray diffraction on single crystal. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising. In this respect, the hybrid -(quinolin-8-yl)-4-chloro-benzenesulfonamide cadmium (II), considered as leading structure for further studies, has an excellent antibacterial activity against (with a diameters of inhibition zones of 21 mm and a minimum inhibitory concentration (MIC) of 19.04 × 10 mg/mL), a very good antibacterial activity against (with a diameters of inhibition zones of 19 mm and a MIC of 609 × 10 mg/mL), and again an excellent antifungal activity against (with a diameters of inhibition zones of 25 mm and a MIC of 19.04 × 10 mg/mL).