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  • Renal effects of soluble gu...
    Stasch, Johannes-Peter; Schlossmann, Jens; Hocher, Berthold

    Current opinion in pharmacology, 04/2015, Letnik: 21
    Journal Article

    Highlights • Chronic kidney disease therapies can be unsuccessful — new options are needed. • NO deficiency is implicated in CKD pathogenesis, and sGC catalyzes cGMP formation. • Preclinically, sGC stimulators and sGC activators provide protective renal effects. • Stimulators and activators of sGC may offer a future, alternative modality for CKD.