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Kinoshita, Tomohiro; Shimoyama, Masanori; Tobinai, Kensei; Ito, Mizuko; Ito, Shin-ichiro; Ikeda, Shuichi; Tajima, Kazuo; Shimotohno, Kunitada; Sugimura, Takashi
Proceedings of the National Academy of Sciences - PNAS, 07/1989, Letnik: 86, Številka: 14Journal Article
Expression of human T-cell leukemia virus type I (HTLV-I) is not detectable by immunofluorescence analysis or RNA blot analysis in most fresh peripheral blood mononuclear cells of patients with adult T-cell leukemia or of asymptomatic HTLV-I carriers. However, in this work, mRNA for the HTLV-I tax1/rex1 genes was detected in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and asymptomatic HTLV-I carriers by using reverse transcription followed by the polymerase chain reaction. By using fresh peripheral blood mononuclear cells, the expression of tax1/rex1 mRNA was detected in five of the six adult T-cell leukemia patients and four of the eight HTLV-I carriers examined. The amounts of tax1/rex1 mRNA detected corresponded to ≈ 105 to 106 times less than that in the HTLV-I-infected MT-2 cell line. These results indicate that, in some individuals infected with HTLV-I, the provirus in circulating blood cells is transcribed in vivo. Thus the expression of viral antigens in circulating blood cells in vivo is suggested.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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