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Vedantham, Suresh, MD; Goldhaber, Samuel Z., MD; Kahn, Susan R., MD, MSc; Julian, Jim, MMath; Magnuson, Elizabeth, ScD; Jaff, Michael R., DO; Murphy, Timothy P., MD; Cohen, David J., MD, MSc; Comerota, Anthony J., MD; Gornik, Heather L., MD; Razavi, Mahmood K., MD; Lewis, Lawrence, MD; Kearon, Clive, MB, PhD
American heart journal/The American heart journal, 04/2013, Letnik: 165, Številka: 4Journal Article
Background Current standard therapy for patients with acute proximal deep vein thrombosis (DVT) consists of anticoagulant therapy and graduated elastic compression stockings. Despite use of this strategy, the postthrombotic syndrome (PTS) develops frequently, causes substantial patient disability, and impairs quality of life. Pharmacomechanical catheter-directed thrombolysis (PCDT), which rapidly removes acute venous thrombus, may reduce the frequency of PTS. However, this hypothesis has not been tested in a large multicenter randomized trial. Study design The ATTRACT Study is an ongoing National Institutes of Health–sponsored, Phase III, multicenter, randomized, open-label, assessor-blinded, parallel two-arm, controlled clinical trial. Approximately 692 patients with acute proximal DVT involving the femoral, common femoral, and/or iliac vein are being randomized to receive PCDT + standard therapy versus standard therapy alone. The primary study hypothesis is that PCDT will reduce the proportion of patients who develop PTS within 2 years by one-third, assessed using the Villalta Scale. Secondary outcomes include safety, general and venous disease-specific quality of life, relief of early pain and swelling, and cost-effectiveness. Conclusion ATTRACT will determine if PCDT should be routinely used to prevent PTS in patients with symptomatic proximal DVT above the popliteal vein.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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