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Agarwal, Sushant; Sebastian, Leve Joseph Devarajan; Gaikwad, Shailesh; Srivastava, M V Padma; Sharma, M C; Singh, Manmohan; Bhatia, Rohit; Agarwal, Ayush; Sharma, Jyoti; Dash, Deepa; Goyal, Vinay; Srivastava, Achal K; Tripathi, Manjari; Suri, Vaishali; Singh, Mamta B; Sarkar, Chitra; Suri, Ashish; Singh, Rajesh K; Vibha, Deepti; Pandit, Awadh K; Rajan, Roopa; Gupta, Anu; Elavarasi, A; Radhakrishnan, Divya M; Das, Animesh; Tandon, Vivek; Doddamani, Ramesh; Upadhyay, Ashish; Vishnu, Venugopalan Y; Garg, Ajay
Scientific reports, 02/2024, Letnik: 14, Številka: 1Journal Article
Primary CNS Vasculitis (PCNSV) is a rare, diverse, and polymorphic CNS blood vessel inflammatory condition. Due to its rarity, clinical variability, heterogeneous imaging results, and lack of definitive laboratory markers, PCNSV diagnosis is challenging. This retrospective cohort analysis identified patients with histological diagnosis of PCNSV. Demographic data, clinical presentation, neuroimaging studies, and histopathologic findings were recorded. We enrolled 56 patients with a positive biopsy of CNS vasculitis. Most patients had cerebral hemisphere or brainstem symptoms. Most brain MRI lesions were bilateral, diffuse discrete to confluent white matter lesions. Frontal lobe lesions predominated, followed by inferior cerebellar lesions. Susceptibility-weighted imaging (SWI) hemorrhages in 96.4% (54/56) of patients, either solitary microhemorrhages or a combination of micro and macrohemorrhages. Contrast-enhanced T1-WIs revealed parenchymal enhancement in 96.3% (52/54 patients). The most prevalent pattern of enhancement observed was dot-linear (87%), followed by nodular (61.1%), perivascular (25.9%), and patchy (16.7%). Venulitis was found in 19 of 20 individuals in cerebral DSA. Hemorrhages in SWI and dot-linear enhancement pattern should be incorporated as MINOR diagnostic criteria to diagnose PCNSV accurately within an appropriate clinical context. Microhemorrhages in SWI and venulitis in DSA, should be regarded as a potential marker for PCNSV.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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