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Yassine, Hussein N; Trenchevska, Olgica; He, Huijuan; Borges, Chad R; Nedelkov, Dobrin; Mack, Wendy; Kono, Naoko; Koska, Juraj; Reaven, Peter D; Nelson, Randall W
PloS one, 01/2015, Letnik: 10, Številka: 1Journal Article
Using mass spectrometric immunoassay, the abundance of SAA truncations relative to the native variants was examined in plasma of 91 participants with type 2 diabetes and chronic kidney disease and 69 participants without diabetes. The ratio of SAA 1.1 (missing N-terminal arginine) to native SAA 1.1 was lower in diabetics compared to non-diabetics (p = 0.004), and in males compared to females (p<0.001). This ratio was negatively correlated with glycated hemoglobin (r = -0.32, p<0.001) and triglyceride concentrations (r = -0.37, p<0.001), and positively correlated with HDL cholesterol concentrations (r = 0.32, p<0.001). The relative abundance of the N-terminal arginine truncation of SAA1.1 is significantly decreased in diabetes and negatively correlates with measures of glycemic and lipid control.
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