This study examines the relationship between proactive coping, future time orientation, and perceived work productivity during the coronavirus (COVID-19) pandemic, based on the work-from-home experience of employees in Taiwan and the United States (U.S.). It draws on the conservation of resources (COR) theory, which posits that proactive coping and future time orientation are crucial personal resources that affect the capacity of an individual to adapt to stressful situations. The results show that in the relationship between proactive coping and perceived work productivity, future time orientation acts as a full mediator in Taiwan and a partial mediator in the U.S. The study extends the application of the COR theory to the context of the COVID-19 pandemic and offers important insights that will enable professionals to assess the role of proactive coping and future time orientation in their productivity evaluations of working tasks and to design appropriate training sessions. •Telecommuting experiences of two samples were examined during COVID-19.•Proactive coping is positively associated with future time orientation and productivity.•Future time orientation served as an important mediator.•Mediating effect was different in two cultural samples.•Eastern cultural sample reported stronger links between examined constructs.