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Gao, Lei; Jiang, Dan; Wen, Xue-Song; Cheng, Xiao-Cheng; Sun, Min; He, Bin; You, Lin-Na; Lei, Peng; Tan, Xiao-Wei; Qin, Shu; Cai, Guo-Qiang; Zhang, Dong-Ying
Respiratory research, 04/2020, Letnik: 21, Številka: 1Journal Article
The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China has been declared a public health emergency of international concern. The cardiac injury is a common condition among the hospitalized patients with COVID-19. However, whether N terminal pro B type natriuretic peptide (NT-proBNP) predicted outcome of severe COVID-19 patients was unknown. The study initially enrolled 102 patients with severe COVID-19 from a continuous sample. After screening out the ineligible cases, 54 patients were analyzed in this study. The primary outcome was in-hospital death defined as the case fatality rate. Research information and following-up data were obtained from their medical records. The best cut-off value of NT-proBNP for predicting in-hospital death was 88.64 pg/mL with the sensitivity for 100% and the specificity for 66.67%. Patients with high NT-proBNP values (> 88.64 pg/mL) had a significantly increased risk of death during the days of following-up compared with those with low values (≤88.64 pg/mL). After adjustment for potential risk factors, NT-proBNP was independently correlated with in-hospital death. NT-proBNP might be an independent risk factor for in-hospital death in patients with severe COVID-19. ClinicalTrials, NCT04292964. Registered 03 March 2020.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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