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Montine, Thomas J.; Phelps, Creighton H.; Beach, Thomas G.; Bigio, Eileen H.; Cairns, Nigel J.; Dickson, Dennis W.; Duyckaerts, Charles; Frosch, Matthew P.; Masliah, Eliezer; Mirra, Suzanne S.; Nelson, Peter T.; Schneider, Julie A.; Thal, Dietmar Rudolf; Trojanowski, John Q.; Vinters, Harry V.; Hyman, Bradley T.
Acta neuropathologica, 01/2012, Letnik: 123, Številka: 1Journal Article
We present a practical guide for the implementation of recently revised National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an “ABC” score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.
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in: SICRIS
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