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Triboulet, Robinson; Mari, Bernard; Lin, Yea-Lih; Chable-Bessia, Christine; Bennasser, Yamina; Lebrigand, Kevin; Cardinaud, Bruno; Maurin, Thomas; Barbry, Pascal; Baillat, Vincent; Reynes, Jacques; Corbeau, Pierre; Jeang, Kuan-Teh; Benkirane, Monsef
Science (American Association for the Advancement of Science), 03/2007, Letnik: 315, Številka: 5818Journal Article
MicroRNAs (miRNAs) are single-stranded noncoding RNAs of 19 to 25 nucleotides that function as gene regulators and as a host cell defense against both RNA and DNA viruses. We provide evidence for a physiological role of the miRNA-silencing machinery in controlling HIV-1 replication. Type III RNAses Dicer and Drosha, responsible for miRNA processing, inhibited virus replication both in peripheral blood mononuclear cells from HIV-1-infected donors and in latently infected cells. In turn, HIV-1 actively suppressed the expression of the polycistronic miRNA cluster miR-17/92. This suppression was found to be required for efficient viral replication and was dependent on the histone acetyltransferase Tat cofactor PCAF. Our results highlight the involvement of the miRNA-silencing pathway in HIV-1 replication and latency.
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Vir: Osebne bibliografije
in: SICRIS
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