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Ren, Zhi-Wei; Li, Yong-Jie; Yu, Tao; Ni, Duan-Yu; Zhang, Guo-Jun; Du, Wei; Piao, Yuan-Yuan; Zhou, Xiao-Xia
Neural regeneration research, 06/2017, Letnik: 12, Številka: 6Journal Article
Brief-pulse stimulation at 50 Hz has been shown to terminate afterdischarges observed in epilepsy patients. However, the optimal pulse stimulation parameters for terminating cortical electrical stimulation-induced afterdischarges remain unclear. In the present study, we examined the effects of different brief-pulse stimulation frequencies(5, 50 and 100 Hz) on cortical electrical stimulation-induced afterdischarges in 10 patients with refractory epilepsy. Results demonstrated that brief-pulse stimulation could terminate cortical electrical stimulation-induced afterdischarges in refractory epilepsy patients. In conclusion,(1) a brief-pulse stimulation was more effective when the afterdischarge did not extend to the surrounding brain area.(2) A higher brief-pulse stimulation frequency(especially 100 Hz) was more likely to terminate an afterdischarge.(3) A low current intensity of brief-pulse stimulation was more likely to terminate an afterdischarge.
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