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  • Are meta-analysis–based com...
    Calderon, Moises A., MD; Andersen, Jens S., PhD; Nelson, Harold S., MD

    Journal of allergy and clinical immunology, 08/2013, Letnik: 132, Številka: 2
    Journal Article

    Because small single-center trials commonly have less variation, their SMDs will be large, not because of a larger effect but because of less variation. ...the random-effects model favors single-center trials and not the guideline-compliant, multinational, multisite confirmatory trials used in modern development of specific immunotherapy. ...moving toward evidence-based medicine implies the integration of individual clinical expertise with the best available external clinical evidence from systematic research.