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Létourneau, Sven, DPhil; Krieg, Carsten, PhD; Pantaleo, Giuseppe, MD; Boyman, Onur, MD
Journal of allergy and clinical immunology, 04/2009, Letnik: 123, Številka: 4Journal Article
IL-2 plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T (Treg) cells, which are required for the maintenance of immune tolerance. Moreover, IL-2 is implicated in the differentiation and homeostasis of effector T-cell subsets, including TH 1, TH 2, TH 17, and memory CD8+ T cells. The IL-2 receptor is composed of 3 distinct subunits, namely the α (CD25), β (CD122), and γ (γc) chains. Of crucial importance for the delivery of IL-2 signals to Treg cells is the expression of CD25, which, along with CD122 and γc, confers high affinity binding to IL-2. Notably, recent findings suggest a novel role for CD25, whereby CD25 molecules on Treg cells and possibly other cells are capable of influencing T-cell homeostasis by means of IL-2 deprivation. This review explores these findings and integrates them into our current understanding of T-cell homeostasis.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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