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Leung, Wayne F.; Chorlton, Samuel; Tyson, John; Al-Rawahi, Ghada N.; Jassem, Agatha N.; Prystajecky, Natalie; Masud, Shazia; Deans, Gregory D.; Chapman, Michael G.; Mirzanejad, Yazdan; Murray, Melanie C.M.; Wong, Patrick H.P.
International journal of infectious diseases, 01/2022, Letnik: 114Journal Article
•Ongoing severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection may occur in immunocompromised hosts.•Sequencing of repeat samples demonstrated an increasing repertoire of mutations.•Viral culture can be used to confirm the presence of infectious SARS-CoV-2. This article reports a case of a 21-year-old woman with refractory B-cell acute lymphocytic leukaemia who presented with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). She remained positive for SARS-CoV-2 by viral culture for 78 days and by polymerase chain reaction (PCR) for 97 days. Sequencing of repeat samples over time demonstrated an increasing and dynamic repertoire of mutations.
