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Ahn, Jung-Min, MD; Lee, Ki Hong, MD; Yoo, Sang-Yong, MD; Cho, Young-Rak, MD; Suh, Jon, MD; Shin, Eun-Seok, MD; Lee, Jae-Hwan, MD; Shin, Dong Il, MD; Kim, Sung-Hwan, MD; Baek, Sang Hong, MD; Seung, Ki Bae, MD; Nam, Chang-Wook, MD; Jin, Eun-Sun, MD; Lee, Se-Whan, MD; Oh, Jun-Hyok, MD; Jang, Jae Hyun; Park, Hyung Wook, MD; Yoon, Nam Sik, MD; Cho, Jeong Gwan, MD; Lee, Cheol Hyun, MD; Park, Duk-Woo, MD; Kang, Soo-Jin, MD; Lee, Seung-Whan, MD; Kim, Jun, MD; Kim, Young-Hak, MD; Nam, Ki-Byung, MD; Lee, Cheol Whan, MD; Choi, Kee-Joon, MD; Song, Jae-Kwan, MD; Kim, You-Ho, MD; Park, Seong-Wook, MD; Park, Seung-Jung, MD
Journal of the American College of Cardiology, 07/2016, Letnik: 68, Številka: 2Journal Article
Abstract Background The long-term prognosis of patients with variant angina presenting with aborted sudden cardiac death (ASCD) is unknown. Objectives The purpose of this study was to evaluate the long-term mortality and ventricular tachyarrhythmic events of variant angina with and without ASCD. Methods Between March 1996 and September 2014, 188 patients with variant angina with ASCD and 1,844 patients with variant angina without ASCD were retrospectively enrolled from 13 heart centers in South Korea. The primary endpoint was cardiac death. Results Predictors of ASCD manifestation included age (odd ratio OR: 0.980 by 1 year increase; 95% confidence interval CI: 0.96 to 1.00; p = 0.013), hypertension (OR: 0.51; 95% CI: 0.37 to 0.70; p < 0.001), hyperlipidemia (OR: 0.38; 95% CI: 0.25 to 0.58; p < 0.001), family history of sudden cardiac death (OR: 3.67; 95% CI: 1.27 to 10.6; p = 0.016), multivessel spasm (OR: 2.06; 95% CI: 1.33 to 3.19; p = 0.001), and left anterior descending artery spasm (OR: 1.40; 95% CI: 1.02 to 1.92; p = 0.04). Over a median follow-up of 7.5 years, the incidence of cardiac death was significantly higher in ASCD patients (24.1 per 1,000 patient-years vs. 2.7 per 1,000 patient-years; adjusted hazard ratio HR: 7.26; 95% CI: 4.21 to 12.5; p < 0.001). Death from any cause also occurred more frequently in ASCD patients (27.5 per 1,000 patient-years vs. 9.6 per 1,000 patient-years; adjusted HR: 3.00; 95% CI: 1.92 to 4.67; p < 0.001). The incidence rate of recurrent ventricular tachyarrhythmia in ASCD patients was 32.4 per 1,000 patient-years, and the composite of cardiac death and ventricular tachyarrhythmia was 44.9 per 1,000 patient-years. A total of 24 ASCD patients received implantable cardioverter-defibrillators (ICDs). There was a nonsignificant trend of a lower rate of cardiac death in patients with ICDs than those without ICDs (p = 0.15). Conclusions The prognosis of patients with variant angina with ASCD was worse than other patients with variant angina. In addition, our findings supported ICDs in these high-risk patients as a secondary prevention because current multiple vasodilator therapy appeared to be less optimal.
