Shwetapradara or Leucorrhoea is a common symptom of genital tract infection in women. The World Health Organization estimated that there are 333 million new cases of curable Vulvo-vaginal infections (VVIs) per year. Physiological excess of vaginal discharge does not require any treatment. But the pathological conditions which necessitate treatment are those involving many infections due to Candida, Trichomonas, Gram negative, Gram positive etc. organisms. For the treatment of Shwetapradara many Kashaya drugs are available in classics. From such recipes, Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchvalkaladi Varti has been selected in one group and in other group Panchvalkaladi Varti is selected. Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchavalkaldi Varti had shown statistically highly significant result on Yonigata symptoms i.e. Yoni Kandu, Yoni Daurgandhya, Yoni Vedana, Yoni Pichchhilata and Yoni Daha, associated symptoms like Katishoola, Udarashoola, Mutradaha & gynaecological complains i.e. Vaginitis, Cervicitis, Vulvitis & in relieving pus cells, fungal hyphae and Gram-ve organism but on basis of percentage relief and inter group comparison better response was observed in trial group A receiving Lodhra Kalka Paan with Nyagrodh Twak Kashaya and Panchavalkaldi Varti. The overall effect of the therapy on 106 patients of Shwetapradara in both groups was evaluated. 86.20%of patients in the Group A and 68.75% of patients in Group B were improved completely. 10.34% of patients in Group A and, 16.66% of patients in Group B were markedly improved. While only14.58% patients were improved in Group B.