E-viri
Recenzirano
Odprti dostop
-
Takatsu-Coleman, André L., PhD; Patti, Camilla L., PhD; Zanin, Karina A., MSc; Carvalho, Rita C., PhD; Borçoi, Aline R., BPharm; Ceccon, Liliane M.B., MSc; Berro, Laís F., BBiomedSc; Frussa-Filho, Roberto, PhD; Zager, Adriano, MSc; Tufik, Sergio, PhD; Andersen, Monica L., PhD
Journal of psychiatry & neuroscience, 07/2013, Letnik: 38, Številka: 4Journal Article
Background Although mood-congruent memory (MCM), or the tendency to recall information consistent with one’s mood, is a robust phenomenon in human depression, to our knowledge, it has never been demonstrated in animals. Methods Mice were subjected to social isolation (SI) or crowding for 12 hours and had their depressive-like behaviour (evaluated by the forced swim, tail suspension, sucrose preference and splash tests) or their serum corticosterone concentrations evaluated. In addition, we determined the temporal forgetting curve of the plus-maze discriminative avoidance task (PM-DAT) and examined the effects of SI or crowding on memory retrieval in the PM-DAT. Finally, we verified the effects of metyrapone pretreatment on reinstatement of memory retrieval or on the increase of corticosterone levels induced by SI. Results Twelve hours of SI produced depressive-like behaviour, enhanced corticosterone concentration and reinstated retrieval of a forgotten discriminative aversive (i.e., negatively valenced) task. Depressive-like behaviour was critical for this facilitative effect of SI because 12 hours of crowding neither induced depressive-like behaviour nor enhanced retrieval, although it increased corticosterone levels at the same magnitude as SI. However, corticosterone increase was a necessary condition for MCM in mice, in that the corticosterone synthesis inhibitor metyrapone abolished SI-induced retrieval reinstatement. Limitations Our study did not investigate the effects of the social manipulations proposed here in a positively valenced task. Conclusion To our knowledge, the present paper provides the first evidence of MCM in animal models.
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Vnos na polico
Trajna povezava
- URL:
Faktor vpliva
Dostop do baze podatkov JCR je dovoljen samo uporabnikom iz Slovenije. Vaš trenutni IP-naslov ni na seznamu dovoljenih za dostop, zato je potrebna avtentikacija z ustreznim računom AAI.
Leto | Faktor vpliva | Izdaja | Kategorija | Razvrstitev | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Baze podatkov, v katerih je revija indeksirana
Ime baze podatkov | Področje | Leto |
---|
Povezave do osebnih bibliografij avtorjev | Povezave do podatkov o raziskovalcih v sistemu SICRIS |
---|
Vir: Osebne bibliografije
in: SICRIS
To gradivo vam je dostopno v celotnem besedilu. Če kljub temu želite naročiti gradivo, kliknite gumb Nadaljuj.