Reconstructive therapies to promote the regeneration of lost periodontal support have been investigated through both preclinical and clinical studies. Advanced regenerative technologies using new barrier‐membrane techniques, cell‐growth‐stimulating proteins or gene‐delivery applications have entered the clinical arena. Wound‐healing approaches using growth factors to target the restoration of tooth‐supporting bone, periodontal ligament and cementum are shown to significantly advance the field of periodontal‐regenerative medicine. Topical delivery of growth factors, such as platelet‐derived growth factor, fibroblast growth factor or bone morphogenetic proteins, to periodontal wounds has demonstrated promising results. Future directions in the delivery of growth factors or other signaling models involve the development of innovative scaffolding matrices, cell therapy and gene transfer, and these issues are discussed in this paper.