Abstract Different reactions channels induced by the 18 O + 40 Ca collisions at 275 MeV incident energy are simultaneously measured and analysed consistently within the same reaction and structure frameworks within the NUMEN project. The project aims to provide data-driven information for the determination of the nuclear matrix elements involved in the neutrinoless double beta decay. In particular, the elastic and inelastic scattering, one- and two-proton transfer, one-neutron transfer, and single charge exchange reactions are explored. The full quantum-mechanical calculations, performed by including microscopic nuclear structure inputs, describe well all the experimental data, giving support to a multi-channel strategy for the analysis of heavy-ion induced direct reactions.