Methane is an abundant and low-cost gas with high global warming potential and its use as a feedstock can help mitigate climate change. Variety of valuable products can be produced from methane by methanotrophs in gas fermentation processes. By using methane as a sole carbon source, methanotrophic bacteria can produce bioplastics, biofuels, feed additives, ectoine and variety of other high-value chemical compounds. A lot of studies have been conducted through the years for natural methanotrophs and engineered strains as well as methanotrophic consortia. These have focused on increasing yields of native products as well as proof of concept for the synthesis of new range of chemicals by metabolic engineering. This review shows trends in the research on key methanotrophic bioproducts since 2015. Despite certain limitations of the known production strategies that makes commercialization of methane-based products challenging, there is currently much attention placed on the promising further development. •From a wide range of bioproducts synthesized by methanotrophic bacteria the most established are PHAs, methanol and SCP.•Recent progress in the field led to novel methane-based products such as sesquiterpenoids, cadaverine, putrescine.•Low gas-liquid mass transfer and methane uptake remain major technological limitations of methane bioconversions.•Low gas-liquid mass transfer and methane uptake remain major technological limitations of methane bioconversions.