Abstract The Legnaro National Laboratories are one of the four INFN laboratories and they are mainly dedicated to experimental nuclear physics and astrophysics, within the field of nuclear structure and dynamics, where heavy ion induced reactions at medium-low energies are involved. Moreover, high level technologies for the construction of particle accelerators and experimental instruments and apparatuses are studied and developed. The laboratory is at present involved in the construction of the SPES facility, which concerns the development of a new research infrastructure devoted to the production of exotic beams for nuclear physics study and new radioisotopes for nuclear medical applications. The heart of SPES is an innovative cyclotron, B70, capable of providing high intensity proton beams (up to 750 μA) in the energy range between 35 and 70 MeV. A description of the present and future challenges at the Legnaro National Laboratory will be given.