I.I.Tosheva, G.A.Ikhtiyarova Abu Ali ibn Sina Bukhara State Medical Institute, Bukhara, Uzbekistan Aim: to analyze causative factors, obstetrical, and perinatal outcomes in women with preterm premature rupture of the membranes (PPROM) and to develop delivery strategy. Patients and Methods: medical records of 106 deliveries (in 2017–2019) in women with PPROM occurred at 37–39 weeks of gestation were analyzed. Anamnestic somatic and obstetrical gynecological data were assessed. The course of current and previous pregnancies, delivery, and postnatal period was described in detail. Laboratory tests, vaginal flora, and Bishop Score used to rate the readiness of the birth canal for labor and other factors (i.e., bleeding, birth defects, antenatal death, chorioamnionitis signs etc.) were evaluated as well. In addition, uterine and fetal ultrasound was performed. Results: mean age of study women was 26.5 years. All women had obstetrical, gynecological, or somatic comorbidities. 22 women with PPROM (20.7%) were characterized by low socieconomic status. 11 women (11.3%) had bad habits, i.e., drug and alcohol addiction, 20.7% (22 women) occupational hazards, and 30.2% (32 women) compromised family history. Conclusions: retrospective analysis of delivery records has demonstrated that compromised obstetrical, gynecological, and somatic history (which occurred in all women) was the key factor promoting PPROM.PPROM resulting from the pathological growth of cervical vaginal flora causes chorioamnionitis in 26.4% of cases thus accounting for significant increase in the prevalence of obstetrical disorders. Keywords: pregnancy, chorioamnionitis, amnion, preterm premature rupture of the membranes, labor induction, vaginal microflora. For citation: Tosheva I.I., Ikhtiyarova G.A. Pregnancy outcomes in preterm premature rupture of the membranes. Russian Journal of Woman and Child Health. 2020;3(1):–19. DOI: 10.32364/2618-8430-2020-3-1-16-19.