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Varoquaux, G.; Gramfort, A.; Poline, J.B.; Thirion, B.
Journal of physiology, Paris, 09/2012, Letnik: 106, Številka: 5-6Journal Article
► Correlations in rest fMRI reveal underlying neural connectivity. ► Small-world connectivity is in apparent contradiction with segregated networks. ► Gaussian graphical models infer the independence structure of brain activity. ► We explore different models assuming varying large-scale graph properties. ► Models imposing a decomposition in small networks cannot fit large-scale structure. Correlations in the signal observed via functional Magnetic Resonance Imaging (fMRI), are expected to reveal the interactions in the underlying neural populations through hemodynamic response. In particular, they highlight distributed set of mutually correlated regions that correspond to brain networks related to different cognitive functions. Yet graph-theoretical studies of neural connections give a different picture: that of a highly integrated system with small-world properties: local clustering but with short pathways across the complete structure. We examine the conditional independence properties of the fMRI signal, i.e. its Markov structure, to find realistic assumptions on the connectivity structure that are required to explain the observed functional connectivity. In particular we seek a decomposition of the Markov structure into segregated functional networks using decomposable graphs: a set of strongly-connected and partially overlapping cliques. We introduce a new method to efficiently extract such cliques on a large, strongly-connected graph. We compare methods learning different graph structures from functional connectivity by testing the goodness of fit of the model they learn on new data. We find that summarizing the structure as strongly-connected networks can give a good description only for very large and overlapping networks. These results highlight that Markov models are good tools to identify the structure of brain connectivity from fMRI signals, but for this purpose they must reflect the small-world properties of the underlying neural systems.
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