The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. In addition to the financial costs, commercial software often lags behind the capabilities of academic software—a natural consequence of the fact that new ideas are often explored first in academia—and commercial software may not be open source, which poses a barrier for some researchers as it can hinder reproducibility. ...of thumb, taking code from one level to the next requires a 5- to 10-fold increase in coding effort. ...I consider that conflating these 2 classes of code deliverables (both of which are common in bioinformatics and computational biology) has hampered progress towards higher standards.