The short half-life of super(212)Bi and super(213)Bi limits the application of these radionuclides in alpha radionuclide therapy. The labeling of biomolecules with super(212)Pb (mother nuclide of super(212)Bi) instead of super(212)Bi or super(213)Bi has the advantage of obtaining a conjugate with a half-life of 10.6 h, compared with of 60 min for super(212)Bi or 46 min for super(213)Bi. Previous attempts to prepare a potential in vivo generator with super(212)Pb complexed by the DOTA chelator failed, because about 36 % of Bi was reported to escape as a result of the radioactive decay super(212)Pb super( beta -) arrow right super(212)Bi. Herein, we report studies on the stability of the super(212)Pb complexes with eight selected polydentate ligands, which demonstrate high affinity for 3+ metal cations. From the ligand studied DOTP and BAPTA show a sufficient super(212)Pb labeling yields but only super(212)Pb-DOTP complex is stable in isotonic solution of sodium chloride making this way radioactivity level of released super(212)Bi is below the limit of detection. It should be emphasized that the DOTP complex is stable only in the case when the concentration of free DOTP exceeds 10 super(-4) M.