This discussion paper aimed to explore various cross-disciplinary approaches (i.e., multi-disciplinary, inter-disciplinary, trans-disciplinary, and post-disciplinary) employed in occupational science research. By describing how these approaches are applied in sample studies, our discussion paper shows that taking a cross-disciplinary approach can broaden understandings of complex societal issues related to health, well-being, and human behaviour. Although our paper is data-free and non-systematic, we present our reflections to encourage discussion on the topic of cross-disciplinary approaches. We also want to open the dialogue for occupational scientists to consciously choose cross-disciplinary approaches in their occupational science work. This will enhance the potential for groundbreaking and impactful processes and outcomes both in research and practice.