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Bensellam, Mohammed; Laybutt, DRoss; Jonas, Jean-Christophe
Molecular and cellular endocrinology, 11/2012, Letnik: 364, Številka: 1-2Journal Article
It is well established that regular physiological stimulation by glucose plays a crucial role in the maintenance of the beta-cell differentiated phenotype. In contrast, prolonged or repeated exposure to elevated glucose concentrations both in vitro and in vivo exerts deleterious or toxic effects on the beta-cell phenotype, a concept termed as glucotoxicity.
