Abstract Introduction Seizure recurrence in the early morning is well known in Juvenile Myoclonic Epilepsy, the presence of seizures happens usually after waking up and there is a clear relationship with sleep as most of the seizures happen in a time frame that involves the next 30 to 120 minutes of wake time after sleep. We wanted to analyze the time frame that is most associated with seizure recurrence as that can have serious implications for safety, not to exclude driving in the morning hours. Methods We investigated on a sample of 20 patients with JME and the pattern on seizure recurrence in the morning. A time frame of wake after sleep was established as follows; the first 30 minutes, 30 to 60 minutes, 60 to 90 minutes and more than 90 minutes. Seizure diaries were given to patients and the seizure recurrence was evaluated. A variable that included earlier waking time in the morning was also taken into account. A follow up of 6 months was given in a retrospective manner. All patients were seen in an outpatient epilepsy clinic. Results All patients were into the JME spectrum, all patients were seen at least 3 times in the follow up time, 70 percent of all cases had at least one event of seizure recurrence, 10 percent had more than 3 events. The majority of the seizures were strongly associated with a wake after sleep time of 60 to 90 minutes. The patients that had an earlier wake time that was out of the usual sleep schedule had increased chances of seizure recurrence. Conclusion Patient with JME have a very close relationship of seizure recurrence with the sleep-wake cycle. The seizure recurrence is strongly associated with a time frame of 90 minutes after waking up. We conclude that the chance of seizure recurrence is less after the 90 minute mark, and that can reasonably be a potential target as far as allowing to drive a motor vehicle passed that time for safety issues. Earlier than usual morning awakenings can precipitate seizures in a greater degree. Support (if any)