Background: Hepatitis E virus (HEV) infection during pregnancy has increased mortality up to 30% in the 3rd trimester.Methods: A prospective study was conducted on the HEV positive pregnant patient with sign symptoms of encephalopathy admitted at the ICU of BRB hospital Ltd during the period of January 2018 to December 2018. During this period 26 patients were admitted. The serum of pregnant women was tested for HEV IgM by ELISA method and positive women were recruited for the study. Maternal variables such as gestational age, clinical progression, worsening of the disease, laboratory parameters, obstetric outcome, and fetal outcome were noted. All data were entered in SPSS 16 and analyzed. This study was ethically approved by the ethical review committee of BRB hospital Ltd.Results: Among 26 HEV-positive patients, the mean age was 27.46 years. Among them 11 (42.3%) were primi and the rest were multigravida, 5 (19.2%) were in the first trimester, 9 (34.6%) were in the 2nd trimester and 12 (46.15%) were in the 3rd trimester of pregnancy.17 patients (65.4%) were housewives and 9 (34.6%) were service holders. Three patients (11.5%) were illiterate, 16 patients (61.5%) have completed primary level of education and 7 (26.9%) were completed higher level of education. Most of the patients were from middle-class families that are 18 patients (69.23%), 3 patients (11.5 %) were from poor social class, and the rest from upper social class is 5 (19.2%).Conclusions: HEV infection during pregnancy has many serious fetomaternal complications including maternal and fetal death.