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Bhardwaj, Neha; Pandey, Satish K.; Mehta, Jyotsana; Bhardwaj, Sanjeev K.; Kim, Ki-Hyun; Deep, Akash
Toxicology research (Cambridge), 05/2018, Letnik: 7, Številka: 5Journal Article
More effective antibiotics are needed to overcome the problem of multidrug resistance. More effective antibiotics are needed to overcome the problem of multidrug resistance. The antibacterial efficacies of three Zn-based nano metal–organic frameworks (nMOFs) – IRMOF-3, MOF-5, and Zn-BTC – were explored, both alone and as mixtures with ampicillin and kanamycin. When tested against Escherichia coli , Staphylococcus aureus , Staphylococcus lentus , and Listeria monocytogenes , the nMOF/drug mixtures demonstrated synergistic (IRMOF-3/kanamycin) or additive (other nMOF/drug combinations) effects compared with the nMOFs or antibiotics alone. Zn-Based nMOFs can reduce the burden of the new discovery of antimicrobial pharmaceuticals by increasing the potency of existing antibiotics.
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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in: SICRIS
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