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Geometric local structure in biological networks
Pržulj, Nataša, 1973-
The recent explosion in biological and other realworld network data has created the need for improved tools for large network analyses. Several new mathematical techniques for analyzing local ...structural properties of large networks have recently been developed. Our work introduces small induced subgraphs of large networks, called graphlets. We use graphlets to develop Žnetwork signaturesŽ that quantify local structural properties of a network. Based on these network signatures, we design two novel Žnetwork agreementŽ measures. These measures lead us to new, well-fitting geometric graph models of biological networks. Models are in turn used to design efficient heuristics.
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