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Tarčno zdravljenje kronične limfocitne levkemije z antagonisti antiapoptotičnih proteinov = Antagonists of antiapoptotic proteins in the targeted therapy of chronic lymphocytic leukemiaAvsec, Damjan, farmacevt, 1993- ; Podgornik, Helena ; Mlinarič-Raščan, IrenaKronična limfocitna levkemija je najpogostejša levkemija pri odraslih v Zahodnem svetu, za katero je značilno kopičenje monoklonskih limfocitov B v krvi, kostnem mozgu in limfatičnih organih. ... Desetletja je zdravljenje temeljilo na kemoterapiji in kemoimunoterapiji, ki so ju v zadnjem desetletju skoraj v celoti nadomestile majhne tarčne molekule. Te delujejo bodisi na receptorsko pot celic B bodisi na antiapoptotični protein Bcl-2. Apoptoza je ključen proces v homeostazi limfocitov B, pri čemer osrednjo vlogo igrajo antiapoptotični proteini iz družine Bcl-2. Ker je vzdrževanje malignih limfocitov B odvisno od antiapoptotičnih proteinov, predstavljajo njihovi antagonisti pomembne učinkovine v boju s kronično limfocitno levkemijo. V tem pregledu predstavljamo razvoj, pomen in prihodnost antagonistov antiapoptotičnih proteinov v tarčnem zdravljenju kronične limfocitne levkemije.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 1, mar. 2022, str. 31-39)Type of material - article, component part ; adult, seriousPublish date - 2022Language - slovenianCOBISS.SI-ID - 103039747
Author
Avsec, Damjan, farmacevt, 1993- |
Podgornik, Helena |
Mlinarič-Raščan, Irena
Topics
Kronična limfocitna levkemija |
Apoptoza |
Bcl-2 |
venetoklaks |
navitoklaks |
S55746 |
obatoklaks
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 73, št. 1, mar. 2022, str. 31-39)
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Avsec, Damjan, farmacevt, 1993- | 52092 |
Podgornik, Helena | 12684 |
Mlinarič-Raščan, Irena | 12443 |
Source: Personal bibliographies
and: SICRIS
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