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The effects of bisphenols on the cardiovascular systemDias, Patrícia, farmacevtka ...Bisphenols, endocrine disrupting chemicals, have frequently been used for producing food packaging materials. The best-known member, bisphenol A (BPA), has been linked to impaired foetal development ... in animals. Possible negative effects of BPA on human health have resulted in the production of novel, so-called next-generation (NextGen) bisphenols whose effects on humans are much less explored or even missing. This review aimed to summarise and critically assess the main findings and shortages in current bisphenol research in relation to their potential impact on the cardiovascular system in real biological exposure. Because of the common presence of bisphenols in daily use products, humans are clearly exposed to these compounds. Most data are available on BPA, where total serum levels (i.e. included conjugated metabolite) can reach up to 430 nM, while free bisphenol levels have been reported up to 80 nM. Limited data are available for other bisphenols, but maximal serum levels of bisphenol S have been reported (680 nM). Such levels seem to be negligible, although in vitro studies have showed effects on ion channels, and thyroid, oestrogenic and androgenic receptors in low micromolar concentrations. Ex vivo studies suggest vasodilatory effects of bisphenols. This stays in clear contrast to the elevation of arterial blood pressure documented in vivo and in observatory cross-sectional human studies. Bisphenols are also claimed to have a negative effect on lipidic spectrum and coronary artery disease. Regardless, the reported data are generally inconsistent and unsatisfactory. Hence novel well-designed studies, testing in particular NextGen bisphenols, are needed.Source: Critical reviews in toxicology. - ISSN 1040-8444 (Vol. 52, iss. 1, 2022, str. 66-87)Type of material - article, component part ; adult, seriousPublish date - 2021Language - englishCOBISS.SI-ID - 104406019
Author
Dias, Patrícia, farmacevtka |
Tvdrý, Václav |
Jirkovský, Eduard |
Sollner Dolenc, Marija |
Peterlin-Mašič, Lucija |
Mladěnka, Přemysl
Topics
Endokrinologija |
Kemikalije |
Kardiovaskularni sistem |
NextGen bisphenol |
blood vessels |
vascular |
endocrine-disruptor |
atherosclerosis |
heart |
NextGen bisfenol |
krvne žile |
ožilje |
endokrini motilec |
ateroskleroza |
srce
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Dias, Patrícia, farmacevtka | ![]() |
Tvdrý, Václav | ![]() |
Jirkovský, Eduard | ![]() |
Sollner Dolenc, Marija | 08519 |
Peterlin-Mašič, Lucija | 19317 |
Mladěnka, Přemysl | ![]() |
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